TNF and Alzheimer disease: In addition, Erjing Pills significantly reduced IL-1β, TNF-α, and IL-6 inflammation-related indices in hippocampal tissues and inhibited the expression of Aβ1–42 and p-Tau404 in the hippocampal area, suggesting that Erjing Pills can reverse microglial activation, reduce the expression level of neuroinflammatory factors, and reduce pathological changes in AD.