TLR4 and Alzheimer disease: In summary, the 5 ingredients of diosgenin, neosibiricoside D, (25S)-pratioside D1, huangjingenin, and dioscin in Erjing Pills have anti-inflammatory activities by acting on TLR4, myeloid differentiation primary response gene 88, inhibitor of kappa B kinase α, inhibitor of kappa B kinase β, NF-kappa-B inhibitor α, and other related targets in the TLR4/NFκB/NLRP3 inflammatory pathway to produce anti-inflammatory effects and thus exert therapeutic efficacy in the treatment of AD.