This process promotes autophagy and induces cytotoxicity in endothelial cells.[19] Researches in human osteoarthritis and rat chondrocytes have confirmed the existence of the Beclin-1-IP3R-Bcl-2 complex within the ER, demonstrating its inhibitory effect on autophagy.[20] Therefore, Bcl-2 may influence [Ca2+]ER release through this complex, thereby regulating autophagy. Here, BCL2 is linked to osteoarthritis.