This activation leads to the Ca2+/CaMKKβ/AMPK pathway being triggered, which promotes a continuous increase in autophagosome formation.[71] Therefore, in advanced PD cases with LRRK2 deficiency, enhancing LRRK2 expression to boost Ca2+-dependent autophagy may represent a novel therapeutic approach for PD. The gene discussed is CAMKK2; the disease is Parkinson disease.