TRPC1 and Parkinson disease: It has been confirmed that the abnormal SOCE mediated by TRPC1 contributes to the damage of dopaminergic neurons in PD.[62] In PD patients and animal models treated with dopaminergic neurotoxins 6-hydroxydopamine, 1-methyl-4-phenylpyridinium (MPP+), or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, downregulation of TRPC1 and autophagy markers has been observed.