Notch signaling is also involved in intestinal epithelial regeneration and ISCs proliferation.[7] Dysregulation of Notch signaling results in loss of ISCs and conversion of amplifying cells into goblet cells.[8] Moreover, defective Notch signaling promotes the growth of colon tumors.[9] We will discuss the Wnt and Notch signaling pathways and Lgr5+ cells and their role in the development of intestinal tumors. This evidence concerns the gene LGR5 and intestinal neoplasm.