LGR5 and colonic neoplasm: [79] To selectively target CSCs, another group of researchers used a fractionated photodynamic therapy technique that significantly suppressed tumor-containing Lgr5+ cells with little effect on normal Lgr5+ stem cells.[80] The previously mentioned technique involving radiation transfer between cells expressing green fluorescent protein and a rose bengal photosensitizer could demonstrate,[80] in concept, a novel photodynamic therapy to specifically target Lgr5+ cells to treat and prevent colon cancer.