LGR5 and cancer: Some food components have anti-cancer effects in CRC.[67] Sulforaphane (SFN) is an isothiocyanate obtained from cruciferous vegetables, such as cabbage, cauliflower, and broccoli, and could be a promising anti-cancer agent.[68] Previous studies have suggested that SFN might have a suppressive effect on various CSCs, including pancreatic, breast, and lung CSCs.[69–71] Chen et al[72] showed that SFN could reduce colorectal CSCs properties by suppressing the Tap63α/LGR5/β-catenin pathway.