NOTCH4 and gastric cancer: Moreover, the interaction between gastric cancer cells and HUVECs promotes cell migration in cell co-culture experiments.[94] In the same year, this research team also showed that Luteolin can reverse EMT by inhibiting the Notch signaling pathway, thereby exerting an anti-gastric cancer effect.[95] In another finding, ribosomal S6 kinase (RSK) has been implicated in the development of triple-negative breast cancer, and RSK is able to phosphorylate Y-box binding protein-1 (YB-1) to upregulate the expression of Notch-4, thereby promoting breast cancer growth and drug resistance.