In another study, Notch-1 overexpression induced an increase in VEGF secretion in Hs-746T gastric cancer cells, whereas VEGF secretion was significantly reduced by treatment with luteolin, and the antitumour effects of inhibition of cell proliferation, migration, tubulogenesis in HUVECs and inhibition of angiogenic mimicry (VM) exerted by treatment with luteolin were rescued by Notch-1 overexpression. The gene discussed is NOTCH1; the disease is gastric cancer.