STAT3 and cancer: S100 calcium-binding protein A7 (S100A7), as a member of the S100 gene family, has the ability to promote the metastasis of cancer cells,[105] Fan et al[106] found that activation of STAT3 was able to upregulate the expression of S100A7 to enhance the metastatic ability of A431-III cells, whereas luteolin acid was able to inhibit the signaling of STAT3, thereby downregulating the expression of S100A7 and thus exerting anticancer effects.