The PI3K/protein kinase B (PKB/AKT) signaling pathway is one of the key signaling pathways that regulate cell growth, modulate the cell cycle, influence angiogenesis and promote proliferation and metabolism, and aberrant activation of this pathway is closely associated with the development of almost all tumors and is the most commonly altered signaling pathway in human cancers.[30,31]. Here, AKT1 is linked to cancer.