The specific mechanism is that this miRNA can target the lipid raft marker protein (FLOT1) in hepatocellular carcinoma cells and reduce its expression to play the role of inhibiting the growth activity of hepatocellular carcinoma cells, and it is worth mentioning that in this study, the overexpression of miR-6809-5p or the downregulation of FLOT1 were both resulted in the inactivation of various signaling pathways such as NF-κB, ERK1/2, and JNK. Here, MAPK3 is linked to hepatocellular carcinoma.