There is a low level of M leprae-specific humoral immunity in TT cases; in contrast, cases that present with an impaired Th2 cytokine response and widespread skin lesions of various types, ranging from diffuse skin involvement to nodular infiltrates (called lepromas), significantly decreased in CD4+ T cells, but rather have numerous CD8+ T cells, containing a higher number of M leprae bacteria, are classified as lepromatous infections.[31,32,38] The leprosy of borderline forms express immunological dynamics. Here, CD4 is linked to leprosy.