A previous review of LGI1 and CASPR2 autoimmunity in children concluded that isolated epilepsy, epileptic encephalopathy or seizure disorder occupied 57.1%(8/14) in CASPR2-positive patients [12], and intractable epilepsy was also reported later in a multi-center study [9].A recent multi-center research has described the epileptic phenotypes in a population with autoimmune encephalitis, and the authors found multiple seizure types and prevalent involvement of temporal regions in patients with CASPR2 antibody-associated encephalitis [13]. This evidence concerns the gene CNTNAP2 and Epileptic encephalopathy.