The brain MRI of the adult patient in the literature showed multiple lesions scattered in brain, brainstem, and cervical and thoracic spinal cord, showing hypointensity on T1-weighted images, hyperintensity on T2-weighted and FLAIR images, with low-titer MOG-IgG in CSF(titer,1:1) and CASPR2-IgG in both serum and CSF (titers, 1:100 and 1:1), and a possible diagnosis of coexisting MOG-IgG-associated disease (MOGAD) and CASPR2 antibody-associated autoimmune encephalitis was established [17]. The gene discussed is MOG; the disease is autoimmune encephalitis.