Brain MRI scan in previous pediatric studies which enrolled less than 10 patients with CASPR2 autoimmunity reported that a minor part of patients showed variable abnormal findings;4 patients with T2 hyperintensity in the brain [10, 11, 14]; 2 with meningeal enhancement [15, 16]; 1 with brain atrophy [11]. This evidence concerns the gene CNTNAP2 and Brain atrophy.