A recent multiple-center study showed that 66.7% (10/15) children with CASPR2 antibody-associated autoimmune encephalitis revealed abnormalities of brain MRI which mainly located in cerebral cortex, thalamus, caudate nucleus, cerebral peduncle, white matter, hippocampus, globus pallidus and corpus callosum [9]. The gene discussed is CNTNAP2; the disease is autoimmune encephalitis.