While analyzing these CRPC-adenocarcinoma and t-NEPC patients’ individual expression for Pax5, ETV5 and KLF12, we further found that both ETV5 and KLF12 expression vary among adenocarcinoma and t-NEPC patients, with sometimes showing higher expression in CRPC adenocarcinoma (Fig. S3B). Here, PAX5 is linked to adenocarcinoma.