On the contrary, AR expression (Fig. S1C) as well as AR driven gene signature such as expression of KLK3, or Nkx3.1 decreased in C4-2BER and DKD (representing t-NEPC) cells as compared to adenocarcinoma C4-2B and C4-2 cells respectively (Fig. 1C). The gene discussed is NKX3-1; the disease is adenocarcinoma.