Moreover, this study unveiled the interconnection between phospholipid metabolism, especially PC, with striatal pathology associated with WDR45 dysfunction in the DAergic system, provided a key molecule, Lpcat1, for the mechanism study of axonal degeneration in BPAN and other neurodegenerative diseases (Fig. 8). The gene discussed is WDR45; the disease is neurodegeneration with brain iron accumulation 5.