Moreover, this study unveiled the interconnection between phospholipid metabolism, especially PC, with striatal pathology associated with WDR45 dysfunction in the DAergic system, provided a key molecule, Lpcat1, for the mechanism study of axonal degeneration in BPAN and other neurodegenerative diseases (Fig. 8). This evidence concerns the gene LPCAT1 and neurodegeneration with brain iron accumulation 5.