NFKB1 and B-cell chronic lymphocytic leukemia: These genes are involved in metabolic reprogramming by regulating metabolic pathways, such as NF-kB and survival signals (R-HSA-209560), which are highly activated in the early stages of CLL and by regulating ChREBP-activated metabolic gene expression (R-HSA-163765), which plays a central role in advanced CLL.