In addition, Odaka et al. [165] found that the number of serum PEVs (CD41+-EVs and CD61+-EVs) was significantly higher in patients with pancreatic ductal adenocarcinoma (PDAC) than in healthy controls and that the areas (AUCs) under the receiver operating characteristic (ROC) curves of CD41+-EVs and CD61+-EVs were 0.678 and 0.652, respectively, indicating that they performed moderately well as diagnostic markers and could assist in diagnosing PDAC. This evidence concerns the gene ITGB3 and pancreatic ductal adenocarcinoma.