The proteins that were downregulated the most in COVID-19 convalescents were the acute phase proteins: C-reactive protein (CRP), serum amyloid A1 and A2 (SAA1 nad SAA2), calprotectin S100A8/A9 and other members of the S100 family (S100-A11, S100-A12) (Fig. 3A). The gene discussed is SAA2; the disease is COVID-19.