The GEPIA2.0 results showed that UBA1 mRNA in pan‐cancer was highly expressed in BRCA, colon adenocarcinoma (COAD), DLBC, ESCA, GBM, LAML, brain lower grade glioma (LGG), LIHC, OV, PAAD, rectum adenocarcinoma (READ), STAD and thymoma (THYM), and significantly downregulated in kidney renal clear cell carcinoma (KIRC) (FC >1.4 or <0.7 and p < 0.01) (Figure 2). The gene discussed is UBA1; the disease is rectum adenocarcinoma.