Through analysing TCGA and GTEx data, we found that UBA1 is significantly overexpressed in gastrointestinal tumours (COAD, ESCA, LIHC, PAAD, READ and STAD), haematological tumours (DLBCL and LAML/AML) and brain tumours (LGG and GBM). The gene discussed is UBA1; the disease is diffuse large B-cell lymphoma.