Some studies have revealed the sensitivity of triple negative breast cancer (TNBC) to UBA1 depletion through genome wide CRISPR/Cas9 screening of TNBC models, targeting UBA1 with the first type of UBA1 inhibitor TAK‐243 induces insoluble endoplasmic reticulum stress and induces cell death by activating upregulation of transcription factor 4.11 Here, UBA1 is linked to triple-negative breast carcinoma.