Cox regression analysis of 33 types of cancer showed a significant correlation between UBA1 expression and OS in 8 types of cancer, including bladder urothelial carcinoma (BLCA) (HR >1, p < 0.05), head and neck squamous cell carcinoma (HNSC) (HR >1, p < 0.05), KIRC (HR <1, p < 0.05), LAML (HR >1, p < 0.05), LGG (HR >1, p < 0.05), LIHC (HR >1, p < 0.05), lung adenocarcinoma (LUAD) (HR >1, p < 0.05) and THCA (HR <1, p < 0.05) (Figure S3A). The gene discussed is UBA1; the disease is head and neck squamous cell carcinoma.