HIVEP3 and osteogenesis imperfecta: Here we sought to determine whether skeletal microenvironmental dysfunction occurs in OI and how this may impact early SSC populations, using a widely studied OI mouse model, Col1a2oim/oim mice (OIM mice) displaying spontaneous fractures.22 We further find evidence that correcting these defects in the skeletal vascular microenvironment can ameliorate the OI phenotype, as SHN3-deficiency can rescue the Col1a2oim/oim model, correcting both the dysregulation in the SSC vascular niche and skeletal fragility in the Col1a2oim/oim model.