HIVEP3 and osteogenesis imperfecta: In considering alternative approaches to augment bone formation and correct any potential vascular microenvironmental defects in OI, Schnurri-3 (SHN3, HIVEP3), a critical negative regulator of bone formation in both mice and humans offers an attractive novel approach.19,20 Mice lacking SHN3 display an osteosclerotic phenotype with profoundly augmented osteoblast activity leading to near absolute protection from age-related bone loss.