Similarly, in the AA GIA sample, the Elastic Net SNP model showed a 35% and 13% enhancement in AUPRC (both Wilcoxon test p-value < 0.001), and 9% and 22% in AUROC (both DeLong test p-value < 0.001) over the APOE-ε4 and best AD PRS model, respectively. Here, APOE is linked to Alzheimer disease.