APOE and Alzheimer disease: In the HLA GIA sample, it outperformed both the APOE-ε4 and the best AD PRS model (AD AFR PRS.psig) by 17% and 4% in AUPRC (both Wilcoxon test p-value < 0.001), and by 2.7% and 4% in AUROC (DeLong test p-value = 0.56 and 0.25), respectively.