HTR2C and major depressive disorder: For example, Htr2c (known as the 5-hydroxytryptamine receptor 2C) plays an important role in the 5-HT transport system, which is closely associated with anxiety and depression.43 Gene ontology (GO) analysis showed that the significantly enriched terms of these DEGs were associated with neurotransmission and cellular component (Supplementary Figure S1D,E).