Systematic phenotyping and characterization have demonstrated that the 3×Tg-AD mouse model of AD (3×Tg) gradually develops neuropathological changes involving both Aβ-plaques and NFT in an age-related fashion across the lifespan of 4 to 18 months.11 This makes the 3×Tg model ideally suitable to examine the development of age-related gut microbial dysbiosis and its pathogenic role in the onset and progression of AD and associated amyloid and tau pathologies. This evidence concerns the gene MAPT and Alzheimer disease.