For example, our protein arrays showed that PPI potentially interacted with the shock transducer and activator of transcription 3 (STAT3) [58–60], mitogen-activated protein kinase 3 (MAPK3) [61–63], the HECT domain, and the Ankyrin Repeat Containing E3 Ubiquitin Protein Ligase 1 (HACE1) [64, 65], all of which are linked to cancer pathogenesis. The gene discussed is HACE1; the disease is cancer.