Therefore, our results indicate that lower LAT1 can improve mitochondrial dysfunction and relieve apoptosis and myocardial fibrosis via the mTOR/Bax/Bcl-2/caspase-3 signaling pathway, and there was a positive feedback loop between LAT1 and mTOR (Figure S8j). This evidence concerns the gene SLC7A5 and Myocardial fibrosis.