SMAD4 and metabolic dysfunction-associated steatohepatitis: Regarding mRNA signatures, there were significant increases in the hepatic expression of YAP1, HSPD1, TNF, TEAD2, ITGB1, FOXA2, MMP14, and SMAD4, with significant decreases in LATS1, LATS2, AMOTL2, SOX11, and NF2 in both NASH groups, as against the Normal group.