IL10 and coinfection: Another study showed that the effects of Mtb/IAV co-infection on Mtb control in mice (e.g., increased bacterial loads, reduced survival, impaired Mtb-specific CD4+ T cell responses, and pulmonary macrophage accumulation with increased arginase-1 production) were rescued upon IL-10 neutralization [79]; this was explained in part by prior reports indicating that type I IFN induced IL-10 expression during Mtb infection [80,81].