,127 Tocotrienols were reported to inhibit angiogenesis in the tumor microenvironment via regulation of hypoxia-inducible factor-1α (HIF-1α) and its downstream target, the VEGF, and other angiogenic factors such as IL-8 and cyclooxygenase 2 (COX-2) in DLD-1 human CRC cells.128. The gene discussed is PTGS2; the disease is colorectal carcinoma.