• Inhibited malignant transformation, cell migration, invasion, and markers for epithelial (E-cadherin) to mesenchymal (vimentin) transition, metastasis (matrix metalloproteinase 9), angiogenesis VEGF, inflammation (NF-κB), and Wnt signaling (β-catenin).• Induced apoptosis in CRC but not normal colon cells.• δT3 had minimal impact on NCM460, which are healthy colon mucosal cells. Here, NFKB1 is linked to colorectal carcinoma.