PARP1 and cancer: • Exertion of anticancer effects through 3 major pathways: apoptosis (BIRC3, BIRC5, caspase-8, caspase-9, and PARP1), transcriptional dysregulation in cancer (CDKN1A, CDKN1B, MMP9, MYC, JUN, and RELA), and cancer progression (caspase-3, CCND1, CTNNB1, VEGFA, and Wnt-1).