NFKB1 and colitis: ,142 For example, daily supplementation of δT3 reduced TNF-α–induced activation of NF-κB in mice with colitis-induced colon cancer through decreased phosphorylation and degradation of the NF-κB polypeptide gene enhancer in B-cells inhibitor, alpha (IκBα) in the cytosol, and inhibited phosphorylation of p65 in the nucleus.72