We identified 7 genes (ITGB1, SNAI1, NOTCH4, STAT5B, RAPGEF3, LAMA2, and GNAI1) that have been implicated in both stemness and the drug response and validated their relevance through an analysis of data from breast cancer patients in the TCGA database using UCSC Xena (Fig. 6F). The gene discussed is RAPGEF3; the disease is breast cancer.