CFTR and male infertility: In order to be able to use the ES strategy as a first‐tier method for male infertility, the sensitivity and specificity of the analysis strategy should exceed 95% for each type of the following “mandatory” anomalies mentioned in current (inter)national guidelines for genetic testing in male infertility5, 6: classical AZF deletions, non‐mosaic sex chromosomal anomalies, and the most common European CFTR variants present in the Elucigene CF‐EU2v1 kit.