On one hand SOX9 has been implicated as an oncogene in different types of cancer (e.g., esophageal squamous cell carcinoma, breast and colorectal cancers) and its adaptable role to participate in different steps of cancer progression, and on the other hand findings suggest that it may also behave as a tumor suppressor (e.g., cervical cancer).27, 28, 29, 30. The gene discussed is SOX9; the disease is cancer.