CD40LG and malaria: IgM‐mediated enhancement has been observed against large antigens such as erythrocytes,34, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65 KLH,21, 64, 66, 67 and malaria parasites,68 while enhancement of responses to small proteins like BSA and OVA has not been reported.