That is, the probands from two unrelated non-consanguineous families possessed the homozygous frameshift variant c.198_200delinsCC affecting CFAP300. It has been previously found in PCD patients of different background including Israeli, German, Slavic and Finnish populations, and is believed to arise from an ancient European founder mutation [24, 26, 42]. The gene discussed is CFAP300; the disease is primary ciliary dyskinesia.