found a significant association between the additive model of rs2853668 and ischemic stroke (HRR = 1.17, p = 0.05, 95% CI = 1.00–1.38).Han et al. [17] showed that the T/G and G/G genotypes of rs2736100 and the G/A and A/A genotypes of rs2853676 were associated with stroke risk (P < 0.05).This study was the first to assess the link between TERT SNPs and CSVD risk, ultimately revealing that rs2853676 and rs2075786 were significantly associated with CSVD even following Bonferroni correction. Here, TERT is linked to ischemic stroke.