It has been theorized that inhibitors of VEGF or the signaling of VEGF receptors (VEGFRs) induce hypertension via decreased production of vasodilators (nitric oxide, prostacyclin), increased production of vasoconstrictors (endothelin-1), and rarefaction of microvascular endothelial cells [11]. The gene discussed is EDN1; the disease is hypertensive disorder.