For instance, as mentioned earlier, the generation of mitochondrial reactive oxygen species (mtROS) not only occurs through changes in complex I (CI) activity but is also maintained at optimal levels through the inactivation/acetylation of Superoxide Dismutase 2 (SOD2), a major mitochondrial antioxidant enzyme, affecting tumor cell migration (Bastin et al. 2023). Here, SOD2 is linked to neoplasm.