CASP3 and plasma cell myeloma: To characterize the proximal pharmacodynamic effects of BRD-810 in vivo, mice engrafted with MOLP-8 multiple myeloma cells were injected with a single dose of 6, 12.5, 25 or 50 mg kg−1 of BRD-810 and then subjected to tumor biopsy at 1, 3, 6, 24, 48 and 72 h to allow the measurement of cleaved caspase 3 levels as an indicator of apoptosis (Fig. 3c).