Secondly, regarding the clustering into SDs and FDs, while some argue that the ADAS-Cog lacks sensitivity in detecting early cognitive decline [77], we found that it yielded similar results to those based on the PACC score, and the ADNI MEM [41, 42] with respect to the evaluated prognostic accuracy of tau PET (Supplementary Fig.s 4, 6). This evidence concerns the gene MAPT and Mental deterioration.