Receiver operator characteristic (ROC) curve analysis of the relative gene expression levels of IL-1β and NLRP3 to discriminate between early (F0, F0-1, F1, and F1-2) and late (F2 + F2-3 + F3) post-MAFLD hepatic fibrosis revealed that IL-1β at cutoff value ≤ 10.98 had an AUC of 0.949, sensitivity of 97.67%, specificity of 92.21%, PPV of 87.5%, and NPV of 98.6% and accuracy of 94.9. The gene discussed is NLRP3; the disease is Hepatic fibrosis.