The validity of relative gene expression levels of IL-1β and NLRP3 in detecting post-MAFLD hepatic fibrosis revealed that IL-1β at cutoff value > 1.1 had an AUC of 0.919, sensitivity of 88.33%, specificity of 96.26%, positive predictive value (PPV) of 96.4%, negative predictive value (NPV) of 88%, and accuracy of 92.3. Here, IL1B is linked to Hepatic fibrosis.