The team used a systems biology approach, integrating experimental, and modelling data from colorectal and other cancer cell lines (including the HCT 116 cell line used herein) and found that the KRAS/MAPK pathway is an important regulator of the circadian system where overexpression of RAS leads to an increase of the circadian period and RAS inhibition results in a shortening of the period. The gene discussed is KRAS; the disease is cancer.