To elucidate the specific signaling pathways that regulated apoptosis in imatinib-resistant CML cells after activation of CDH13, we tested the changes in expression of key proteins from the SAPK/JNK, TRAIL/FADD, and NF-κB signaling pathways using western blotting (Fig. S5). The gene discussed is MAPK8; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.