Our results are coherent with other reports indicating that mood regulation requires functional clockwork in such depression-implicated regions: studies in stress models have also shown elevated nighttime Cry expression in the nucleus accumbens (NAc)44, and dysregulation of a range of core clock genes including Cry2 and Per1/2 in the basolateral amygdala45. This evidence concerns the gene CRYL1 and depressive symptom measurement.