Following treatment with varying concentrations of Corosolic acid (0, 10, 20, and 40 μM) for 48 hours, we observed a dose-dependent decrease in HK3, O-GlcNAcylation, and PD-L1 protein levels in ccRCC cells (Fig. 9D). This evidence concerns the gene CD274 and nonpapillary renal cell carcinoma.