Furthermore, shHK3 suppressed both basal levels and OGT-elevated PD-L1 and O-GlcNAcylation (Fig. 3L, M), signifying that the high basal level of tumor HK3, along with OGT-induced HK3, both played a role in PD-L1 expression following OGT stimulation. Here, OGT is linked to neoplasm.