CD4 and neoplasm: Batf3/Irf8-dependent type 1 DCs (DC1s) are important in the cross-presentation of tumor antigens to CD8+ T cells, Irf4-dependent type 2 DCs (DC2s) prime and polarize antigen-specific CD4+ T helper (Th) cells,15Irf4-dependent monocytic DCs (moDCs) are capable of CD8+ T cell cross-priming16 and prime CD8+ T cells, regulatory DCs (mregDCs) produce large amounts of interleukin-12 (IL-12) ubiquitously,17 and plasmacytoid DCs (pDCs) can produce large quantities of type I interferons.18