ITGAM and neoplasm: ,14 Several factors in the PDAC microenvironment contribute to impaired DC function: tumor-derived TGF-β, IL-10, and IL-6 suppress DC survival and proliferation,55 MDSCs inhibit DC maturation,55 and a subset of immunosuppressive CD11b+ DCs can induce Treg generation and cytotoxic T cell (CTL) suppression.56