KRAS and neoplasm: To determine whether TNFR1 signaling in hematopoietic cells was responsible for suppressing anti-tumor immunity, lethally irradiated 8-week-old KPC mice, which spontaneously develop multifocal K-ras-driven PDAC at approximately 10–14 weeks of age,30 were reconstituted with WT or Tnfr1−/− bone marrow (BM).