TF and hemochromatosis type 1: In apparent contrast to the Powell et al22 study and our findings, Laine et al47 studied 57 female and 21 male p.C282Y homozygotes from a French community screening program (mean age approximately 45) and found that increasing BMI was associated with lower rates of clinical expression of hemochromatosis (based on transferrin saturation) in the women (in models adjusting for various factors including ferritin levels).