Our studies show that genes like ATM, ATRX, RAD51C, along with members of the Fanconi Anemia pathway (FANC-B, C, E, I, L, and M), and SETD2, the methyltransferase regulating H3K36me3, were all associated with the combination of H3K36me3, γH2AX and enhanced R-loops (Fig 6D). This evidence concerns the gene ATRX and Fanconi anemia.