PPRC1 and bacterial infectious disease with sepsis: While proP mutants were not attenuated during cochallenge, we did generate a proQ mutant in C. freundii UMH14 that was not polar on prc and found it to be significantly attenuated in the bacteremia model [Log10 competitive indices in spleen and liver were -0.169 (p < .05) and -0.502 (p < .05), respectively], supporting the Tn-Seq prediction that proQ is indeed a fitness factor.