Overall, phagocytic cells from IFNLR1-/- mice, including macrophages and monocytes, neutrophils, and dendritic cells, had a significantly higher frequency and total number of dsRed+ cells at both 6 and 24 hours post bacterial infection without any alteration in recruited numbers into the lung (Figs 3A and S3A–3C). Here, IFNLR1 is linked to bacterial infectious disease.