Among the mRNAs showing interactions with biomarker candidate miRNAs in this study (hsa-miR-181b, hsa-miR-143, hsa-miR-130a, hsa-miR-224, hsa-miR-188, and hsa-miR-501, Table 2), DDIT4, PLA2G4A, RAB27B, CD163, CALCRL, SLC8A1, CRISPLD1, SCHIP1, LGALSL, SORT1, PDE7B, HTR1F, CLIP4, PRDM16, RTN1, KCNJ2, CPNE8, KIAA0087, FHL1, STOX2, GLIS3, and ADAMTS3 were significantly correlated with the survival of patients with AML in the TCGA database analysis (Fig 5). This evidence concerns the gene PLA2G4A and acute myeloid leukemia.