Among the mRNAs showing interactions with biomarker candidate miRNAs in this study (hsa-miR-181b, hsa-miR-143, hsa-miR-130a, hsa-miR-224, hsa-miR-188, and hsa-miR-501, Table 2), DDIT4, PLA2G4A, RAB27B, CD163, CALCRL, SLC8A1, CRISPLD1, SCHIP1, LGALSL, SORT1, PDE7B, HTR1F, CLIP4, PRDM16, RTN1, KCNJ2, CPNE8, KIAA0087, FHL1, STOX2, GLIS3, and ADAMTS3 were significantly correlated with the survival of patients with AML in the TCGA database analysis (Fig 5). The gene discussed is PDE7B; the disease is acute myeloid leukemia.