Moreover, neutrophil derived EVs carrying tissue factor (TF+ MPO+) have been shown to be elevated in COVID-19 patients [39] as well as in inflammatory conditions, such as anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), and they are associated with increased thrombin generation [40]. Here, F3 is linked to anti-neutrophil cytoplasmic antibody-associated vasculitis.