The importance of EVs carrying tissue factor (TF+EVs) was described in two previous studies where no notable distinctions were observed among EVs subsets between moderate and severe forms of COVID-19 [20], except for TF+EVs; the activity of TF expressed on EVs is significantly higher in patients with severe disease when compared to those with a moderate form of the illness [19, 20]. Here, F3 is linked to COVID-19.