A large number of studies have found that DXM inhibits the expression and activity of iNOS, reduces NO production, constricts blood vessels, raises blood pressure, improves arterial constriction and endothelial dysfunction in septic shock rats, and facilitates reversal of the hypotensive state and restoration of the vascular responsiveness to the regulation of the organism [46–48], which is consistent with our study. Here, NOS2 is linked to septic shock.