Under the intervention of DXM, the levels of serum TNF-α, MIP-1α, SCR, BUN, NO and the ratio of lung W/D decreased, and the pathological changes of lung and kidney were alleviated, which showed that DXM played an anti-inflammatory role in sepsis and alleviated sepsis-induced lung and renal injury. The gene discussed is CCL3; the disease is Sepsis.