[4] This study describes the evaluation of a first-of-its-kind combination (dual antigen and CRP) RDT, the STANDARDTM Q Malaria/CRP DUO (S-DUO; SD Biosensor, Deogyeong-daero, South Korea) test, for the diagnosis of malaria (malaria antigen band); in distinguishing bacterial infection and as a guidance for the prescription of antibiotics (CRP band to detect above 20 mg/L); in a clinical setting in Lambaréné, Gabon, a highly malaria-endemic region. This evidence concerns the gene CRP and malaria.