CRP and malaria: S-DUO RDT has the potential to complement clinical management of non-malarial febrile illness in malaria-endemic regions if a specific detection limit of the CRP component is determined; if determined, the finding of (1) a positive malaria test and negative CRP result and no clinical signs would provide reassurance that malaria could be treated on an outpatient basis without administration of antibiotics, (2) a negative malaria test and negative CRP result would suggest symptomatic management and non-prescription of an antibiotic.