VEGFA and colorectal carcinoma: According to the above informatics, qRT-PCR was used to detect the expression of MMP3, MMP9, TIMP1, VEGFA in CRC cells after luteolin treatment, and found that luteolin might down-regulate the expression of MMP3, MMP9, TIMP1, VEGFA in RKO cell lines, and only the expression of MMP3, MMP9 was decreased in SW480 (Figure 7K, 7L).