There were 144 KEGG enrichment items in total, and the top 10 items were displayed according to p-values < 0.05 (Supplementary Table 9), included Hepatitis B, Prostate cancer, AGE-RAGE signaling pathway in diabetic complications, Hepatitis C, PI3K/AKT signaling pathway, HIF-1 signaling pathway, Kaposi sarcoma-associated herpesvirus infection (Figure 4D, 4E). This evidence concerns the gene HIF1A and Familial prostate cancer.