NRAS and acute myeloid leukemia: While our NRAS cohort demonstrates that NRAS alone can induce an AML-like phenotype, its frequency (1 in 16) is substantially lower than when NRAS is co-expressed with 9a (1 in 4), even though NRAS is likely expressed at higher levels in NRAS animals than it is in 9a+NRAS animals, due to the second gene position effects in the latter (Liu et al., 2017) (Fig. 1A).