These genes included stem cell marker, cmyb, and lineage restriction effectors that are known targets of R::RT1 in AML, such as cepba and pu.1 (myeloid factors) and gata1a (erythroid) (see Table S2 for probe information) (Choi et al., 2006; Stengel et al., 2021). The gene discussed is SPI1; the disease is acute myeloid leukemia.