Across a variety of solid tumor cell lines (TNBC, ovarian cancer, and pancreatic cancer), exposure to the GR ligand dexamethasone induced chemoprotection to paclitaxel, docetaxel, and gemcitabine that was reversed by the addition of ORIC-101 (Fig. 1A and B). The gene discussed is NR3C1; the disease is familial pancreatic carcinoma.