Across a variety of solid tumor cell lines (TNBC, ovarian cancer, and pancreatic cancer), exposure to the GR ligand dexamethasone induced chemoprotection to paclitaxel, docetaxel, and gemcitabine that was reversed by the addition of ORIC-101 (Fig. 1A and B). Here, NR3C1 is linked to ovarian carcinoma.