TREX1 and small cell lung carcinoma: Our data suggest that in chemoresistant SCLC cells, which are continuously exposed to chemotherapy-derived DNA damage, DNA exonucleases like TREX1 may play a crucial role as an adaptive resistance mechanism to suppress cGAS-STING pathway activation due to the constant accumulation of chemotherapy-induced micronuclei or other forms of cytosolic DNAs.