TREX1 and small cell lung carcinoma: Given that TREX1 degrades dsDNA in the cytoplasm, particularly in micronuclei in which cGAS senses aberrant dsDNA accumulation (33), we then evaluated whether there were any variations in the accumulation of dsDNA and the recruitment of cGAS in micronuclei in SCLC cells after CRISPR-mediated TREX1 knockout.