TREX1 and small cell lung carcinoma: To investigate the effects of TREX1 depletion in chemoresistant SCLC cell lines, we utilized CRISPR-Cas9 system-mediated TREX1 knockout (sgTREX1) in H69AR and NCI-H196 cells (Fig. 2A), both of which showed higher drug resistance than H69 cells (Supplementary Fig. S2A).