Although our findings suggest that TREX1 plays an important role in suppressing cGAS-STING pathway activation due to the accumulation of chemotherapy-induced DNA damage in drug-resistant SCLC, representing a promising target for inducing antitumor immune responses, a direct link between TREX1 upregulation and chemoresistance remains to be elucidated. The gene discussed is CGAS; the disease is small cell lung carcinoma.