TREX1 and small cell lung carcinoma: Furthermore, although we demonstrated that TREX1 contributed to the survival and growth of cisplatin-resistant SCLC cells in xenograft models, the association of TREX1 and chemoresistance is still limited because of the lack of a chemoresistant SCLC model in an immunocompetent system, in which the impact of an immune response triggered by TREX1 depletion might be relevant.