TREX1 and small cell lung carcinoma: Similar effects on cell growth were also observed in NCI-H2081 (SCLC-A subtype) and H1048 (SCLC-P subtype) cells (Supplementary Fig. S2E and S2F), whereas no significant effect was observed on HEK293T and FC1010 cells (Supplementary Fig. S2G and S2H), suggesting that TREX1 plays a crucial role in the survival and growth of drug-resistant cells.