SOD1 and amyotrophic lateral sclerosis: More recently, Kosuge et al. (2018) [241] found that EP2 was upregulated in the motor neurons of symptomatic ALS mice (B6SJL-Tg [SOD1-G93A]dl 1Gur/); this study showed the importance of EP2 in PGE2-induced cell death in differentiated motor-neuron like cells, as discussed previously [242].