Tumor methylome data was downloaded from TCGA for five breast invasive carcinomas from different subtypes (1 luminal A, 1 luminal B, 1 basal-like, 2 HER2), two rectum adenocarcinoma and two colon adenocarcinoma (Supplementary Table S1, Supplementary File S2). This evidence concerns the gene ERBB2 and invasive breast carcinoma.